David A Boothman Selected Research

NAD (NADH)

1/2020	MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer.
1/2020	Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.
1/2019	NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers.
1/2019	Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses.
1/2019	NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance.
11/2018	Following anticancer drug activity in cell lysates with DNA devices.
7/2017	Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
1/2016	NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer.
11/2015	Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.
10/2013	Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.

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David A Boothman Research Topics

Disease

72	Neoplasms (Cancer) 01/2021 - 09/2003
10	Pancreatic Neoplasms (Pancreatic Cancer) 11/2017 - 01/2005
9	Lung Neoplasms (Lung Cancer) 01/2019 - 07/2007
8	Necrosis 10/2018 - 10/2010
7	Prostatic Neoplasms (Prostate Cancer) 12/2016 - 03/2003
5	Carcinogenesis 12/2018 - 10/2003
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2015 - 07/2007
5	Breast Neoplasms (Breast Cancer) 10/2013 - 03/2003
5	Colonic Neoplasms (Colon Cancer) 04/2011 - 07/2003
4	Adenocarcinoma 11/2017 - 01/2015
4	Glioblastoma (Glioblastoma Multiforme) 10/2016 - 04/2009
4	Genomic Instability 01/2016 - 12/2004
3	Squamous Cell Carcinoma of Head and Neck 01/2020 - 10/2018
3	Turcot syndrome 02/2016 - 10/2003
2	Squamous Cell Neoplasms (Squamous Cell Cancer) 01/2020 - 12/2015
2	Triple Negative Breast Neoplasms 11/2018 - 07/2014
2	Carcinoma (Carcinomatosis) 10/2016 - 02/2010
2	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2014 - 07/2007
2	Glioma (Gliomas) 08/2013 - 05/2009
2	Phototoxic Dermatitis (Phototoxicity) 12/2011 - 05/2011
2	Neoplasm Metastasis (Metastasis) 03/2011 - 02/2010
2	Microsatellite Instability 01/2004 - 10/2003
1	Leukemia 10/2016
1	Melanoma (Melanoma, Malignant) 10/2016
1	Hypersensitivity (Allergy) 01/2016
1	Nausea 12/2015
1	Vomiting 12/2015

Drug/Important Bio-Agent (IBA)

35	beta-lapachoneIBA 01/2020 - 03/2003
24	quinone (benzoquinone)IBA 01/2020 - 01/2005
22	NAD (NADH)IBA 01/2020 - 01/2005
21	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 03/2003
15	EnzymesIBA 01/2020 - 10/2006
15	Proteins (Proteins, Gene)FDA Link 02/2016 - 07/2003
14	Pharmaceutical PreparationsIBA 11/2018 - 03/2003
10	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 07/2007
9	MicellesIBA 12/2016 - 11/2006
8	Adenosine Triphosphate (ATP)IBA 01/2019 - 10/2010
7	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 10/2010
7	NADP (NADPH)IBA 01/2021 - 10/2006
7	ClusterinIBA 09/2013 - 12/2004
6	Antineoplastic Agents (Antineoplastics)IBA 12/2016 - 10/2006
5	Small Interfering RNA (siRNA)IBA 01/2021 - 01/2006
5	ProdrugsIBA 01/2019 - 04/2005
4	CatalaseIBA 01/2019 - 10/2013
3	Radiation-Sensitizing AgentsIBA 01/2020 - 07/2014
3	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2019 - 05/2009
3	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2018 - 01/2014
3	CaspasesIBA 02/2016 - 07/2007
3	Transcription Factors (Transcription Factor)IBA 06/2014 - 09/2003
3	Poly (ADP-Ribose) Polymerase-1IBA 10/2013 - 09/2006
3	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2011 - 12/2006
3	PolymersIBA 01/2009 - 01/2006
2	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021 - 01/2020
2	AntioxidantsIBA 01/2021 - 01/2015
2	CarbonIBA 01/2021 - 11/2017
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 07/2017 - 01/2013
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2016 - 01/2014
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 02/2010
2	IntegrinsIBA 12/2015 - 11/2006
2	ErbB Receptors (EGF Receptor)IBA 12/2014 - 05/2009
2	deoxynyboquinoneIBA 07/2014 - 06/2012
2	Phosphotransferases (Kinase)IBA 01/2014 - 07/2007
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2014 - 03/2008
2	epidermal growth factor receptor VIIIIBA 08/2013 - 05/2009
2	IonsIBA 01/2013 - 10/2010
2	poly(lactide) (polylactic acid)IBA 12/2011 - 10/2007
2	CalpainIBA 10/2010 - 03/2003
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2009 - 05/2009
2	TOR Serine-Threonine KinasesIBA 10/2009 - 05/2009
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 05/2009 - 07/2007
2	NF-kappa B (NF-kB)IBA 04/2009 - 09/2003
2	mu-calpainIBA 04/2005 - 03/2003
1	Glutathione (Reduced Glutathione)IBA 01/2021
1	Folic Acid AntagonistsIBA 01/2020
1	Methotrexate (Mexate)FDA LinkGeneric 01/2020
1	Pemetrexed (MTA)FDA Link 01/2020
1	Cisplatin (Platino)FDA LinkGeneric 01/2020
1	HMGB1 Protein (HMG1)IBA 01/2019
1	Interferon Type IIBA 01/2019
1	rucaparibIBA 12/2018
1	Pyruvic Acid (Pyruvate)IBA 11/2017
1	PolyestersIBA 01/2017
1	AerosolsIBA 01/2017
1	Focal Adhesion Protein-Tyrosine KinasesIBA 12/2016
1	SeleniumIBA 10/2016
1	AzidesIBA 10/2016
1	QuinonesIBA 10/2016
1	Alkynes (Acetylenes)IBA 10/2016
1	CopperIBA 10/2016
1	PeroxidesIBA 06/2016
1	AntiemeticsIBA 12/2015
1	Histone Deacetylases (Histone Deacetylase)IBA 12/2015
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 12/2015
1	romidepsin (FK228)FDA Link 12/2015

Therapy/Procedure

29	Therapeutics 01/2019 - 03/2003
12	Drug Therapy (Chemotherapy) 01/2020 - 01/2005
9	Radiotherapy 01/2021 - 01/2005
1	Palliative Care (Palliative Therapy) 01/2020
1	Adjuvant Radiotherapy 01/2020
1	Precision Medicine 12/2018